Jon Brown

Dr. Jon Brown is a Clinical Professor in the Department of Clinical and Biomedical Sciences at the University of Exeter, UK. His research focuses on understanding neuronal network changes in neurodegenerative diseases such as Alzheimer’s and schizophrenia, using mouse models to explore synaptic and intrinsic neuronal properties. He leads the Exeter Applied Neurophysiology Group and collaborates with the NIHR Exeter Biomedical Research Centre. Dr. Brown holds a PhD from the University of Bristol (2004), following an MRes (2000) and BSc (1999) from the University of Manchester. His work integrates electrophysiological recordings, transcriptomics, and computational modeling to uncover mechanisms underlying cognitive deficits. He advises postgraduate students and engages in external examining roles.

His research interests include synaptic dysfunction, network integrity in dementia, and the role of neuronal oscillations in disease. Recent studies investigate spatial transcriptomics in mouse models and the impact of tau pathology on sensory encoding. Dr. Brown’s publications span neurophysiology, molecular biology, and translational neuroscience, with a focus on early biomarkers and therapeutic targets.

Education:

• PhD, University of Bristol, UK (2004)
• MRes, University of Manchester, UK (2000)
• BSc, University of Manchester, UK (1999)

Research Interests:

• Cognitive dysfunction in Alzheimer’s and frontotemporal dementia
• Neuronal network dynamics in neurodegenerative diseases
• Mouse models of tauopathy and schizophrenia
• Synaptic physiology and circuit-level analysis
• High-density EEG and spatial transcriptomics

Lab/Team: Exeter Applied Neurophysiology Group.