Francesco Marangoni

Francesco Marangoni, PhD, is an Assistant Professor at the Department of Physiology & Biophysics, University of California, Irvine (UCI) School of Medicine. His research focuses on the molecular mechanisms underlying platelet formation and immune regulation.

His work examines the role of cytoskeletal dynamics in megakaryocyte differentiation, particularly how proteins like CDC42, N-WASP, and Src family kinases regulate proplatelet formation (PPF) and demarcation membrane system (DMS) development. Recent studies highlight his contributions to understanding the interplay between cytoskeletal signaling and platelet-related pathologies, including Wiskott-Aldrich syndrome.

Key research trends include:

• Elucidating GTPase signaling pathways in hematopoietic cells
• Investigating phosphorylation defects in cytoskeletal proteins
• Linking platelet dysfunction to autoimmune and inflammatory diseases