Naoto Hoshi

Naoto Hoshi, PhD, is an Associate Professor in the Department of Physiology & Biophysics at the University of California, Irvine (UCI) School of Medicine. His research focuses on molecular mechanisms of ion channel regulation, particularly KCNQ (M-type) potassium channels, calmodulin dynamics, and kinase/phosphatase interactions.

• Research Themes:
  • Neuronal excitability and epilepsy
  • Protein phosphorylation in channel function
  • Calmodulin and PIP2 signaling
  • Modulation by endogenous compounds (e.g., DHEAS, hydrogen sulfide)

His work has revealed how CK2 and PP1 anchored to KCNQ2 complexes dynamically regulate channel activity, impacting memory consolidation and seizure pathology. Collaborative studies span neurology, reproductive physiology, and cardiovascular research.

• Grants:
  • R01 NS49119 (NIH/NINDS)
  • T32 HD007430 (NIH/NICHD)
  • R01 NS067288 (NIH/NINDS)

Dr. Hoshi's lab employs advanced electrophysiology, molecular biology, and pharmacology to investigate channelopathies and develop novel neuromodulatory therapies.