معرفی
Joav Prives serves as a Professor in the Department of Pharmacological Sciences at Stony Brook University, where his research centers on the molecular regulation of neurotransmitter receptors in neuromuscular systems. His work bridges cellular and molecular pharmacology with neurobiology through investigations of receptor biogenesis and membrane dynamics.
His academic foundation includes:
- Ph.D. from McGill University
- Postdoctoral training at Weizmann Institute of Science, Israel
Prives' research program systematically dissects the regulation of nicotinic acetylcholine receptor (AChR) expression, with emphasis on endoplasmic reticulum-mediated folding, chaperone-assisted assembly (particularly involving calnexin), and phosphorylation-dependent topogenesis. His laboratory employs primary chick muscle cells and transfected models to investigate how N-linked glycosylation, disulfide bond formation, and cytoskeletal interactions govern receptor clustering and dispersal at neuromuscular junctions. This work provides fundamental insights into receptor trafficking disorders and synaptic maintenance mechanisms.
Analysis of his publication record (1993-2000) reveals a cohesive trajectory exploring AChR biogenesis through biochemical and cell biological approaches. His work consistently integrates signal transduction principles with receptor pharmacology, demonstrating how small GTPases (Rac/Cdc42) and phosphorylation events regulate receptor clustering. The research spans molecular neuroscience, membrane biology, and protein biochemistry with implications for myasthenia gravis and related neuromuscular pathologies.
No scientific awards were documented in the source materials.
While the texts confirm active laboratory research through 2000, specific details regarding graduate student mentorship, grant funding, or collaborative teams were not provided in the available documentation.
