معرفی
Farid Kadyrov is an Associate Professor at the Department of Biochemistry and Molecular Biology within the Southern Illinois University School of Medicine. His research focuses on the molecular mechanisms of DNA mismatch repair (MMR) and its role in genome stability, particularly in relation to triplet repeat expansion associated with neurodegenerative diseases and cancer.
- Education: PhD in Biochemistry (1997) from the Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences; Postdoctoral training with Jan Drake (NIEHS) and Paul Modrich (Duke University).
Kadyrov’s work has elucidated key components of the MMR pathway, including MutSα, MutLα, and EXO1, and their roles in correcting DNA replication errors and suppressing carcinogenic mutations. His studies also explore the collaboration between MMR proteins and chromatin assembly factors like CAF-1 and ASF1A. Recent publications highlight his contributions to understanding MutLγ’s role in triplet repeat expansion and the impact of histone modifications on repair processes.
Kadyrov’s laboratory has reconstituted critical MMR reactions using purified proteins and defined DNA substrates, revealing insights into endonuclease activation, strand incision, and DNA gap repair. His findings have implications for cancer genetics and neurodegenerative disease mechanisms.
Contact: fkadyrov@siumed.edu
