Anna Pluciennik

Anna Pluciennik serves as an Assistant Professor in the Department of Biochemistry & Molecular Biology within the College of Life Sciences at Thomas Jefferson University, where she bridges molecular mechanisms with neurodegenerative disease research.

Her primary research focuses on DNA repair pathways in triplet repeat expansion disorders, particularly spinal and bulbar muscular atrophy (SBMA) and Huntington's disease. She investigates critical molecular players including PCNA, FAN1 nuclease, and deubiquitinases like USP7, examining their roles in genome stability, protein quality control, and disease pathogenesis through structural, biochemical, and cellular approaches.

Analysis of her publication record reveals a concentrated research trajectory centered on nucleases in DNA repair and ubiquitin signaling in neurodegeneration. Her work consistently explores how DNA mismatch repair mechanisms and protein degradation pathways contribute to triplet repeat instability, with strong implications for therapeutic development in incurable neurodegenerative conditions.