معرفی
Dr. Fabrizio Pertusati is a Lecturer at the School of Chemistry, Cardiff University, with expertise in organic and medicinal chemistry. He holds an MSc in Physical Organic Chemistry from the University of Turin and a PhD in asymmetric organic chemistry from Cardiff School of Chemistry. His academic journey includes postdoctoral training at Emory University and in the laboratory of Nobel laureate Prof. George Olah at the University of Southern California.
Dr. Pertusati's research focuses on the design and synthesis of small molecules as therapeutics against rare diseases (including congenital disorder of glycosylation, Niemann-Pick, Cystinosis, and GNE myopathy), infectious diseases, and antifungal drug discovery. His key expertise areas include organofluorine chemistry, organophosphorus chemistry, carbohydrate chemistry, and the design and synthesis of phosphate/phosphonate prodrugs of carbohydrate scaffolds.
His recent publications demonstrate a strong focus on nucleoside prodrug technologies (particularly ProTide technology), with applications in antiviral therapy, anticancer agents, and treatment of rare metabolic disorders. His work often involves interdisciplinary collaborations with researchers specializing in lysosomal storage diseases, biofilm formation, and antimicrobial resistance.
Dr. Pertusati serves as a reviewer for numerous prestigious journals including Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, and Organic Letters. He has also been a reviewer for MRC-fellowship grants and was a member of the Scientific Advisory Board of Ichorion Therapeutics (2017-2018).
His teaching portfolio includes courses on industrial applications of biocatalysis, techniques in drug discovery, drug targets, drug development from laboratory to clinic, and introduction to drug development.
