Solen Josse

Solen Josse serves as a Lecturer at the University of Picardie Jules Verne, affiliated with the Glycochemistry and Agroresources Laboratory (UR 7378) in Amiens, France. Her research operates under the "Chemistry for the Living" axis, focusing on the synthesis of bioactive compounds at the chemistry-biology interface.

Dr. Josse's research program centers on glycochemistry-driven drug discovery, with three interconnected pillars: (1) Developing TSAO-family nucleoside derivatives as antiviral agents against HIV and HCV; (2) Engineering cyanohydrin/aminocyanide intermediates for stereoselective spiroheterocyclic sugar synthesis; (3) Creating antiproliferative nucleoside analogs with isothiazole/oxathiole modifications for cancer therapy. Her work uniquely bridges carbohydrate chemistry with medicinal applications through innovative synthetic methodologies.

Analysis of her 2014-2019 publications reveals consistent output in high-impact venues, demonstrating expertise in nucleoside analog design and green synthetic chemistry. Key trends include strategic phosphorus substitutions in antiviral compounds, metal-free carbohydrate modifications, and kinetic control in acetal formation – all contributing to sustainable drug development pipelines. Her research shows strong translational potential with a patent for antitumor agents.

As part of the Glycochemistry and Agroresources Laboratory, Dr. Josse contributes to a collaborative ecosystem focused on sustainable chemistry and agroresource valorization. The lab provides comprehensive infrastructure for organic synthesis, biological testing, and structural analysis, supporting both fundamental research and applied therapeutic development projects within the University of Picardie's scientific framework.