Evi Kostenis

Prof. Dr. Evi Kostenis is a Professor at the Institute of Pharmaceutical Biology at the University of Bonn. Her research focuses on G-protein-coupled receptors (GPCRs), investigating their signaling mechanisms, molecular interactions with downstream effectors like G proteins and arrestins, and their implications for therapeutic development. She employs CRISPR-Cas9 genome editing and pharmacological tools to elucidate GPCR functions in health and disease.

Her work integrates molecular biology, pharmacology, and cellular biology to uncover fundamental principles of GPCR signaling. Recent studies emphasize translating these findings into innovative treatments, particularly targeting oncogenic G proteins in cancer. Collaborative projects involve interdisciplinary teams and partnerships with institutions like the University Hospital Bonn and international labs.

Key achievements include pioneering the use of compounds like FR900359 for studying Gq-regulated processes and advancing understanding of beta-arrestin signaling pathways. Her lab’s research bridges basic science and clinical applications, contributing to drug discovery for complex diseases.