معرفی
Dr. Esen Sefik is an Assistant Professor in the Department of Immunobiology at Yale University School of Medicine. She holds affiliations with the Center for Infection and Immunity, Immunobiology, and the Janeway Society. Her research focuses on host-microbe interactions, immune system development, and chronic infections, utilizing humanized mouse models to study diseases like fibrosis, cancer, and inflammation. She received her B.S. from Yale College and her PhD in Immunology from Harvard University.
Dr. Sefik’s work explores how microbiota influence immune cell regulation, particularly T cell differentiation, and their role in maintaining tissue homeostasis. Her postdoctoral research modeled humanized mice for severe COVID-19 and fibrotic diseases, revealing insights into macrophage-driven lung pathology and immune cell contributions. Her lab investigates therapeutic advancements through engineered mouse models and collaborative studies with experts like Richard Flavell and Akiko Iwasaki.
Key research themes include regulatory T cell dynamics, tumor immunity (via IL-7R licensed CD8+ T cells), and the interplay between microbial ecosystems and immune responses. Her publications span immunology, virology, and bioinformatics, emphasizing translational applications in human health.
