Erik Martinez-Hackert

Erik Martinez-Hackert is an Associate Professor in the Department of Biochemistry and Molecular Biology at Michigan State University. He holds a Ph.D. from Rutgers University and completed postdoctoral training at the Leukemia and Lymphoma Society of America. His research focuses on TGFβ signaling pathways, particularly the functional mechanisms of Nodal, Cerberus, Lefty, and Activins in disease contexts.

Research Goals:

• Elucidate molecular mechanisms of TGFβ family pathways
• Link dysregulated pathways to human diseases (e.g., breast cancer)
• Develop protein-based inhibitors targeting these pathways

Key Findings:

• Cerberus suppresses aggressive breast cancer phenotypes via TGFβ antagonism
• Structural insights into Cripto-1’s role in Nodal-ALK4 signaling

Publications reflect expertise in TGFβ superfamily signaling, receptor-ligand interactions, and therapeutic applications. His work spans structural biology, cell signaling, and translational research.