Brian K. Law

Brian K. Law is an Associate Professor at the University of Florida, specializing in cancer biology and molecular oncology. His research focuses on cyclin-dependent kinases (Cdks) in mammary tumorigenesis, chromosomal instability, and the roles of mTOR and TGFβ signaling pathways. The Law Lab also investigates mechanisms of breast cancer invasion and metastasis, particularly the regulation of E-cadherin and CDCP1 proteins.

Research Interests:

• Cdk Regulation in Cancer: Examines how Cdks drive tumor formation through dysregulated cell proliferation and genetic instability. Uses novel models to test non-ATP competitive Cdk inhibitors and therapeutic strategies targeting mTOR and TGFβ pathways.
• Metastasis Mechanisms: Studies CDCP1's role in E-cadherin dysfunction and its impact on tumor invasion. Explores epithelial-mesenchymal transition (EMT) and its connection to breast cancer metastasis.

Key Findings: The lab has discovered novel Cdk inhibitors, elucidated epigenetic regulators like LSD1 and histone deacetylases in cancer, and developed in vivo models to study EMT-driven metastasis. Collaborations include exploring marine-derived compounds like largazole for cancer treatment.

Labs/Teams: The Law Lab at the University of Florida serves as a hub for interdisciplinary research, integrating molecular biology, pharmacology, and cancer biology to advance therapeutic strategies.