Calvin Roskelley

Dr. Calvin Roskelley is Professor in the Department of Cellular & Physiological Sciences at the University of British Columbia. His laboratory investigates molecular mechanisms regulating tissue architecture in breast and ovarian cancers, developing 3D models to study how cell adhesion disruptions enable tumor invasion and metastasis.

Research centers on epithelial cell behavior, focusing on cadherin-mediated adhesion complexes and integrin signaling pathways that control migratory transitions. His team examines extracellular matrix interactions driving cancer progression using advanced cell culture systems recapitulating in vivo microenvironments.

Publications demonstrate expertise in mammary gland biology and tumor microenvironment studies. Key contributions include identifying senescent cell biomarkers and elucidating gene fusion events in rare carcinomas.

He mentors graduate students and research associates in projects examining cytoskeletal reorganization, anoikis resistance, and metastasis suppression strategies.