معرفی
Eric E. Alani is a Professor in the Department of Molecular Biology and Genetics at Cornell University, part of the College of Agriculture and Life Sciences (CALS). He leads the Alani Lab, focusing on DNA mismatch repair (MMR) and genome stability mechanisms in yeast, with implications for human colorectal cancer and infertility. His research integrates genetics, biochemistry, and single-molecule approaches to study MMR protein interactions during meiosis and vegetative growth.
Dr. Alani holds academic roles including former Director of Graduate Studies and NIH T32 Program Director. He teaches advanced courses like BioMG6330: DNA Biology, emphasizing experimental design and critical analysis. Over 23 PhD students, 8 postdoctoral fellows, and 28 undergraduates have completed training in his group. His work includes collaborations with biophysicists and population geneticists, funded by NIH grants.
Key research projects include analyzing MLH1-MLH3 roles in crossover formation, MMR protein-DNA interactions via fluorescence microscopy, and understanding how MMR prevents recombination between divergent sequences. His lab explores genetic incompatibilities in yeast strains affecting mutation rates and adaptation, with broader implications for pathogenicity studies.
- Awards: 2009 Carpenter Memorial Advising Award
- Teaching: BioMG6330, BioMG7800, and others
- Labs: Located in 459 Biotechnology Building, Ithaca, NY
