معرفی
Edward Gunther, MD is a Professor in the Department of Medicine, Division of Hematology and Oncology at Penn State College of Medicine and the Penn State Cancer Institute. His research focuses on breast cancer mechanisms using genetically modified mouse models to uncover molecular and cell biological mechanisms of cancer development and progression.
His research interests include:
- Breast cancer progression and relapse mechanisms
- Transgenic mouse modeling of mammary tumors
- Oncogene function in carcinogenesis
- Tumor cell heterogeneity and subclone cooperation
- Minimal residual disease and dormancy
Dr. Gunther's recent publications reveal how different oncogenes shape premalignant clone progression in breast cancer models, mechanisms of relapse-proficient subclones with collateral sensitivity to oncogene overdose, and carcinogen-specific mutation patterns in Ras-Raf pathway oncogenes. His work demonstrates how reproductive history influences cancer development and how long-lived premalignant clones can evade natural protective mechanisms.
His scientific recognition includes:
- Outstanding Research Publication award (2014) for his Nature paper on tumor heterogeneity
- Substantial social media and academic engagement for his research (658 Mendeley readers for the Nature paper)
Dr. Gunther has received continuous National Cancer Institute funding as Principal or Co-Principal Investigator for multiple projects spanning nearly two decades:
- Genetic Analysis of Breast Cancer Progression in Mice Using Inducible Transposition (2017-2018)
- Modeling breast cancer relapse prevention in mice (2010-2016)
- Preclinical Modeling of Latent Breast Cancer in Mice (2005-2010)
- BRCA1 FUNCTION USING AN INDUCIBLE TRANSGENE (1999-2005)
His laboratory at the Penn State Cancer Institute's Next-Generation Therapies division maintains an active research program investigating the molecular mechanisms of breast cancer progression, dormancy, and relapse using sophisticated genetically engineered mouse models that closely mimic human disease processes.
