معرفی
Prof. Dindial Ramotar is a Full Professor at the Faculty of Medicine, Department of Medicine, Université de Montréal. His research focuses on structural and functional characterization of eukaryotic proteins involved in DNA repair mechanisms, particularly those targeting oxidative DNA damage, with implications in cancer biology. He is affiliated with the Centre de recherche de l'Hôpital Maisonneuve-Rosemont (CRHMR).
His research expertise spans Biochemistry, Molecular Biology, and Genetics, with a concentration on respiratory cancers. Methodologically, his work is fundamental, employing yeast and Caenorhabditis elegans models to study DNA repair pathways and anticancer drug resistance.
Grants & Projects:
- 2017–2023: Role of C. elegans AP endonuclease in removing DNA lesions caused by toxic compounds (CRSNG Discovery Grant)
- 2017–2022: Linking OCT1 transporter defects to anthracycline resistance in cancer patients (IRSC Project Grant)
- 2016–2018: Microcalorimetry system for molecular interaction studies (CRSNG Research Tools)
Advising & Training: Supervised over 20 graduate students (Master's and Ph.D.), including studies on DNA repair enzymes (e.g., APN-1), stress response mechanisms, and drug resistance pathways in yeast and C. elegans.
Labs & Teams: Active in CRHMR, collaborating on interdisciplinary projects involving DNA repair, oxidative stress, and cancer therapeutics.