Dimitra P. Vageli

Dimitra P. Vageli is a Research Scientist in the Department of Neurology at Yale School of Medicine with extensive expertise in molecular biology, molecular pathology, and cancer biology. She is affiliated with the Yale Cancer Center, Cancer Signaling Networks Program, Center for Neuroscience and Regeneration Research, and the Larynx Lab, where she leads research on head and neck cancer mechanisms and neurological disorders.

Her academic background includes:

• Bachelor's Degree in Sciences, specializing in Biology from the University of Patras, Greece
• Post-graduate Scholarship in Radiation Biology and Radiation Physics from National Centre for Scientific Research 'Demokritos' in Athens, Greece
• Ph.D. in Molecular Oncology and Biotechnology from the Medical School of Crete, University of Crete, Greece (1998)

Dr. Vageli's research program focuses on:

• Mechanisms of neoplastic transformation under exposure to risk factors like bile reflux and tobacco smoke
• Role of transcription factors (NF-κB, STAT3, EGFR) in early oncogenic events
• miRNA research for diagnostic biomarkers in cancer
• Investigating the role of ion channels in neurological disorders
• Chronic inflammation pathways in carcinogenesis

Her publication record demonstrates consistent scholarly contributions with numerous articles in high-impact journals. Her research has evolved from initial groundbreaking work on bile reflux and hypopharyngeal carcinogenesis to broader investigations of molecular pathways, biomarker discovery, and connections between neurological disorders and cancer biology. Recent work includes systematic reviews on biomarkers in atherosclerosis and glioblastoma, reflecting expanding research interests.

Her notable recognition includes:

• Author Service Award 2025
• Springer Nature Editor of Distinction Award 2025
• Ohse Research Awards (2013-2014 and 2014-2015)

Dr. Vageli maintains active collaborations both within Yale and internationally, particularly with Greek research institutions. Her work bridges basic molecular research with translational applications, employing advanced technologies including whole transcriptome and small RNA sequencing analyses. Her research program continues to advance understanding of cancer mechanisms and identify potential targets for prevention, diagnosis, and treatment.

Her laboratory work in the Larynx Lab utilizes in vivo models, molecular biology techniques, and advanced sequencing technologies to investigate the progressive effects of carcinogenic exposures on mucosal tissues, with particular emphasis on DNA damage, miRNA deregulation, and histological changes during early cancer development.