Diane Hawley

Diane Hawley is a Professor in the Department of Chemistry and Biochemistry at the University of Oregon, within the College of Arts and Sciences. Her research focuses on the molecular mechanisms of transcription and DNA repair, particularly involving RNA polymerase II.

Education:

• B.A., University of Kansas, 1976
• Ph.D., Harvard University, 1982 (Advisor: William R. McClure)
• Postdoctoral Training: Rockefeller University, 1983–1986 (Advisor: Robert G. Roeder)

Her research centers on the enzymology of RNA polymerases and the regulation of eukaryotic transcription. Key areas include transcription elongation, termination, transcription-coupled repair (TCR), and the role of TATA-binding protein (TBP) in preinitiation complex assembly. She investigates how RNA polymerase II coordinates multiple enzymatic functions, including intrinsic nuclease activity and proofreading, using biochemical and genetic approaches in yeast and mammalian systems.

The available publications reflect a strong focus on transcriptional mechanisms, DNA-protein interactions, and fidelity in gene expression. Her work spans structural biochemistry, molecular genetics, and functional analysis of transcription machinery.

Scientific Awards:

• NSF Predoctoral Fellow (1976–1979)
• NIH Postdoctoral Fellow (1983–1986)
• NSF Presidential Young Investigator Award (1987–1992)
• Searle Scholar Award (1987–1990)

Diane Hawley has mentored numerous students and postdoctoral researchers, though specific names are not listed. Her lab has been supported by major grants from the NSF and NIH. She has been at the University of Oregon since 1986, contributing significantly to research and academic training in molecular biology.

Her research group employs biochemical, biophysical, and genetic methods to dissect the functional properties of transcription factors and RNA polymerase II. While no formal lab name is mentioned, her team continues to explore fundamental questions in gene regulation and DNA repair.