معرفی
Stewart Shuman, MD, PhD, is a Professor at Weill Cornell Medicine's Graduate School of Medical Sciences, affiliated with the Molecular Biology Program and Department of Medicine. His lab at Sloan Kettering Institute investigates nucleic acid transaction enzymes, integrating biochemistry, structural biology, and genetics to study RNA repair, DNA ligases, and the RNA polymerase II CTD code.
- BA in Biology (1976, Wesleyan University)
- PhD in Molecular Biology (1983, Albert Einstein College of Medicine)
- MD (1981, Albert Einstein College of Medicine)
- Residency in Internal Medicine (1986, Mass General Hospital)
Research spans five areas: topoisomerase mechanisms (e.g., TOPO-cloning), mRNA capping enzymes (revealing antiviral targets), DNA ligase structure (NHEJ pathways in mycobacteria), RNA repair pathways (RtcB ligases), and CTD code decoding (phosphorylation-driven transcription regulation). His work has identified novel drug targets in fungal tRNA splicing systems.
Key awards include the NIH MERIT Award (2007), American Cancer Society Research Professorship (2005–), and the Simon H. Rifkind Chair (1999–). The lab has mentored 38 graduate students since 1988, with alumni in academic and pharmaceutical leadership roles.
- 2015: American Academy of Arts and Sciences
- 2013: American Academy of Microbiology Fellow
- 2007: NIH MERIT Award
His interdisciplinary approach bridges virology, enzymology, and microbial pathogenesis, with publications spanning RNA ligase mechanisms, DNA repair kinetics, and structural analyses of catalytic intermediates.
