Diana Imhof

Prof. Diana Imhof is a Professor at the Pharmaceutical Institute of the University of Bonn, where her research focuses on pharmaceutical biochemistry and bioanalytics. Her work emphasizes synthesis, function, and analysis of bioactive peptides with therapeutic relevance, particularly exploring disulfide-rich peptides like tridegin and conotoxins. She investigates heme interactions with proteins, including their roles in coagulation pathways, TLR4 signaling, and G-protein modulation. Her lab develops advanced bioanalytical methods for studying protein stability and interactions.

Research interests include peptide design for drug delivery, heme-driven pathologies, and molecular mechanisms of protein-ligand interactions. Notable projects involve creating bicyclic peptide libraries to modulate Gαi/s proteins and analyzing heme effects in hemolytic disorders and infections. Collaborative work with international partners advances understanding of heme biology's role in diseases like Parkinson’s and thrombosis.

Publications span 20+ years, with recent contributions exploring heme-protein interactions, Edman degradation for peptide analysis, and TLR4 signaling mechanisms. Her work bridges chemistry and biology, contributing to translational medicine and drug development.