معرفی
David Sherman is a Professor and Chair of the Department of Microbiology at the University of Washington School of Medicine, with an Adjunct Professor appointment in Global Health. His research focuses on the molecular genetics, systems biology, and pathogenesis of Mycobacterium tuberculosis (Mtb), while leading interdisciplinary efforts in drug discovery for TB and other mycobacterial infections.
Key research areas include:
- Gene Regulatory Networks: Investigating how Mtb transcription factors coordinate gene expression during infection cycles.
- Drug Discovery: Developing novel antibiotics and drug combinations, including contributions to pretomanid (anti-TB agent) and elucidating rifampicin tolerance mechanisms.
- Systems Biology: Using computational models to predict bacterial fitness and drug synergy.
Recent publications highlight innovations in:
- ODELAM technology for rapid drug resistance detection
- Machine learning approaches to TB fitness prediction
- Terpene nucleoside biosynthesis mechanisms
- Host-pathogen interactions in alveolar macrophages
Notable achievements include defining the mutation behind BCG vaccine attenuation and pioneering systems biology frameworks for TB research. The Sherman Lab trains PhD students and postdoctoral scholars while collaborating with computational biologists, structural biologists, and chemists globally.
