Carl F. Nathan

Carl F. Nathan is the R.A. Rees Pritchett Professor of Microbiology and Professor of Microbiology and Immunology & Medicine at Weill Cornell Medical College. His research focuses on Mycobacterium tuberculosis biology at the basic-translational interface, particularly host-pathogen interactions, macrophage immunity, and antimicrobial resistance mechanisms. The Nathan Lab investigates both pathogen-directed and host-directed therapies for TB, with a long-standing interest in reactive oxygen/nitrogen intermediates and iNOS regulation. The lab collaborates with Sabine Ehrt's, Kyu Rhee's, and Dirk Schnappinger’s labs, plus Jeremy Rock at Rockefeller University and the Center for Global Health at Weill Cornell.

• Key discoveries: IFN-γ as macrophage activator, TGF-β/IL-10 as deactivating factors, ROI/RNI effector systems, Mtb resistance genes (proteasome, Uvr pathway)
• Translational work: First cytokine therapy for leprosy, current TB drug screening pipelines