Shabaana Khader

Dr. Shabaana Khader serves as a Professor in the Department of Microbiology at the University of Chicago. Her research focuses on Mycobacterium tuberculosis immunology, vaccine development, and host immune responses across single and co-infections.

• NIH-funded research on TB vaccine adjuvants (R61AI169071, U01AI160406)
• Co-investigator in multiple cross-disciplinary studies involving HIV/TB interactions (R01AI184623, R01AI155024)

Key research themes include:

• Vaccine Development: Novel Th1/Th17-inducing subunit vaccines, mucosal immunization strategies
• Immunometabolism: Macrophage metabolic reprogramming by drug-resistant TB strains
• Trained Immunity: Epigenetic regulation of bone marrow progenitors by BCG vaccination
• Cytokine Networks: IL-17, IFN, and S100 family dynamics in infectious diseases

Recent publications emphasize:

• Th1/Th17 axis modulation in TB vaccines
• Neutrophil biology during influenza and TB
• Lung lymphoid follicle formation mechanisms
• Multi-pathogen immune interactions in HIV/TB co-infections