W. Henry Boom

W. Henry Boom is a Professor in the Department of Molecular Biology and Microbiology at Case Western Reserve University School of Medicine. He serves as Chief of the Division of Infectious Diseases & HIV Medicine and Director of the Tuberculosis Research Unit. His research focuses on T cell immunity, cytokine regulation, and antigen processing in Mycobacterium tuberculosis infection.

• Academic Affiliation: Case Western Reserve University School of Medicine
• Key Roles: Division Chief, Director of Tuberculosis Research Unit

Research interests include:

• Mechanisms of M. tuberculosis immune evasion
• CD4+/CD8+/gamma delta T cell responses
• Role of cytokines (IL-2, IL-12, IFN-gamma, IL-10, TGF-beta)
• MHC-II antigen processing and presentation
• TLR receptor interactions with mycobacterial lipoproteins

Recent publications highlight investigations into:

• TLR2 signaling in innate immunity
• MHC-II downregulation by BCG
• Transcriptional regulation of CIITA
• Integrin-mediated T cell adhesion
• Cytokine gene associations in TB pathogenesis

He also leads the Tuberculosis Research Unit, integrating clinical and basic research to combat tuberculosis.