Stephen Jennings

Stephen Jennings, PhD, is a Professor in the Department of Microbiology & Immunology at Drexel University College of Medicine and Co-Director of the Master of Science in Immunology Program. He holds a PhD from the University of Melbourne (1982). His research focuses on the immunological mechanisms controlling HSV-1 infection, including interactions between innate and adaptive immune responses, CD8+ T cell dynamics, and dendritic cell function. Key areas include viral latency, immune evasion, and the role of cytokines like type I IFNs in antiviral defense.

Research Interests: Optimal immune protection against HSV-1 involves synergy between innate (e.g., NK cells, dendritic cells) and acquired immunity (e.g., CD8+ T cells). Current projects investigate CD25+ vs. CD25- CD8+ T cell subpopulations' roles in limiting HSV-1 spread to the nervous system, IL-2/IL-15 signaling in T cell memory, and how dendritic cell-derived type I IFNs activate immune cascades. Studies also explore viral genes impairing DC function and TLR roles in neurotropic HSV-1 replication.

Recent Articles Highlight Trends: His 2018 work models HSV-1 pathogenesis in cutaneous infections, while 2015 and 2013 papers analyze animal models and T cell/NK cell interactions. Earlier work (2009–2006) emphasizes DC requirement for antiviral immunity and CD4+ T cell priming of CD8+ responses. Early studies (2000) address cytokine regulation of endothelial barriers and EHV-1-induced lung pathology.

Advising/Grants: No specific grant details or student advisees listed, though his lab collaborates on NIH-funded projects studying HSV-1 immune evasion and DC biology. Affiliated with Drexel's Institute for Molecular Medicine & Infectious Disease and the Immunology (IMNO) Program.

Labs/Teams: Leads a lab focused on viral immunopathogenesis, with collaborations on TLR signaling and antiviral immunity.