معرفی
David Poyner is a Professor of Pharmacology at Aston University, affiliated with the College of Health and Life Sciences and the Pharmacology & Translational Neuroscience Research Group. His research focuses on neuropeptide receptors, particularly calcitonin gene-related peptide (CGRP) and adrenomedullin receptors, with emphasis on their structure, function, and role in drug discovery. He holds a PhD from the University of Cambridge and has extensive postdoctoral experience in pharmacology and molecular neurobiology. His work integrates molecular and pharmacological approaches to study GPCR signaling pathways and receptor-subunit interactions.
Dr. Poyner teaches molecular pharmacology, cell receptors, and signal transduction across pharmacy and neuroscience programs at Aston. His research collaborations span institutions in the UK and internationally. He leads the Pharmacology and Translational Neuroscience Research Group and directs research activities in his department. Key projects include investigating GPCR:RAMP interactions using nanobodies (funded by BBSRC) and studying receptor component proteins' roles in GPCR modulation.
His recent publications emphasize GPCR structural biology, oxidative stress effects on adenosine receptors, and the pharmacology of CGRP and adrenomedullin in cardiovascular systems. He has contributed to databases like GtoPdb, advancing GPCR pharmacology resources. His lab employs techniques like mutagenesis, styrene-maleic acid copolymer-based solubilization, and molecular dynamics simulations to explore receptor function.
Dr. Poyner coordinates pharmacology teaching at Aston and co-leads the MaC theme on the MPharm program. His research group actively engages in drug discovery efforts targeting receptors involved in cardiovascular diseases, migraine, and arthritis.
