معرفی
David Klatzmann is a Professor of Immunology at Sorbonne University’s Faculty of Medicine and Head of the Biotherapy Department at Pitié-Salpêtrière Hospital. He has held multiple roles including Research Unit Director and entrepreneur, founding four startups and securing over 35 patents. His career combines medical practice, fundamental research, and clinical translation, with significant contributions to HIV discovery and immunotherapy development.
Education: Medical degree (1980), Doctorate in Science (1986), post-doctoral training under Nobel laureate Richard Axel at Columbia University (1987). Key affiliations include Sorbonne University, Pitié-Salpêtrière Hospital, and collaborations with the Institut Pasteur and ERC-funded projects.
Research focuses on regulatory T cells, interleukin-2 (IL-2) therapies, autoimmune diseases, and maternal immune activation’s impact on neurodevelopmental disorders. His work spans clinical trials for SLE, bipolar depression, and allergy; vaccine development using viral-like particles; and integrating machine learning for immunological data analysis. Recent studies highlight IL-2’s role in gut microbiota modulation and pain management in osteoarthritis.
His articles emphasize IL-2’s therapeutic potential across 13 autoimmune diseases, T cell dysfunction in neurodegenerative and inflammatory conditions, and the interplay between immune system and pregnancy. The Nobel Prize in Medicine (2008) recognized his HIV research contributions, while an ERC grant (2012) supported work on regulatory T lymphocytes.
Advising and grants: No formal advisees listed, but has led numerous clinical and translational research projects, including open-label studies in systemic sclerosis and multi-center trials for allergy treatments. His entrepreneurial ventures aim to bridge academic research with commercial applications in immunotherapy.
Labs/Teams: Directs a research unit at Pitié-Salpêtrière, collaborates with Columbia University and the Institut Pasteur, and leads teams in his startups focused on biotherapies, vaccine development, and gene therapy applications.
