معرفی
David J. Sharp is a Professor at Albert Einstein College of Medicine, holding joint appointments in the Department of Molecular Pharmacology, Department of Ophthalmology & Visual Sciences, and the Dominick P. Purpura Department of Neuroscience. His research focuses on microtubule roles in cell division, motility, and morphogenesis, with applications in therapeutic development for wound healing, neural regeneration, and cardiovascular disease. He collaborates with the Friedman, Nosanchuk, and Zhou labs on nanoparticle-based therapies targeting microtubule regulators.
Research interests include:
- Chromosome segregation mechanisms via mitotic spindle dynamics (Pacman-Flux model)
- Microtubule regulation of cell motility, particularly roles of Katanin and uncharacterized enzymes
- Translation of microtubule-targeting strategies into clinical therapies
Publications span microtubule dynamics, spindle architecture, and therapeutic applications. His work bridges basic cell biology with translational medicine, addressing cancer metastasis, spinal cord injury, and cardiovascular pathologies.
Collaborations involve interdisciplinary teams developing novel drug delivery systems. No awards explicitly listed, though his prolific publication record indicates significant contributions to the field.
