David Dingli

David Dingli, M.D., Ph.D., is a Professor of Medicine at Mayo Clinic in Rochester, Minnesota, with primary appointments in the Division of Hematology, Department of Internal Medicine and a joint appointment in the Department of Molecular Medicine. His interdisciplinary research bridges mathematical modeling and clinical hematology to advance cancer and blood disorder therapies.

• Education: M.D. from University of Malta; Ph.D. in Molecular Biology from Mayo Clinic Graduate School of Biomedical Sciences; completed residency and fellowship at Mayo Clinic; visiting scientist at Harvard University, University of Lisbon, and Max Planck Institute.
• Board Certifications: American Board of Internal Medicine (Hematology); Fellow of multiple prestigious colleges including Royal College of Physicians (Edinburgh, London, Glasgow) and American College of Physicians.

Dr. Dingli's research focuses on tumor virotherapy and mathematical modeling of hematopoiesis and clonal evolution. His lab develops computational models to simulate tumor-immune-virus interactions, guiding the design of oncolytic viruses and optimizing clinical outcomes. He investigates disorders like multiple myeloma, PNH, AL amyloidosis, and POEMS syndrome, with emphasis on stem cell transplantation and novel therapeutics like complement inhibitors and CAR-T cells.

His recent publications (2023–2025) reveal a strong focus on clinical outcomes in plasma cell disorders, especially response prediction, transplant strategies, and real-world effectiveness of new therapies (e.g., pegcetacoplan, daratumumab). Key themes include clonal dynamics, risk stratification, treatment sequencing, and biomarker discovery, often leveraging large datasets and collaborative multi-center studies.

Scientific Awards and Honors:

• Donald C. Balfour Award for Meritorious Research
• Bellman Prize (Mathematical Bioscience)
• J. W. Forrester Award (Systems Dynamics Society)
• Early Career Development Award, Mayo Clinic
• Merit Award, American Society of Clinical Oncology
• Winner, National Medical Jeopardy
• Fellow, Royal College of Physicians (all three UK branches)
• Chartered Biologist, Society of Biology, UK

Dr. Dingli is deeply involved in clinical and academic leadership, including directing the Bone Marrow Transplant Fellowship Training Program, serving as Education Director for the transplant program, and mentoring numerous trainees. He has been a grant reviewer for national foundations and an active member of professional societies such as the American Society of Hematology, American Society for Blood and Marrow Transplantation, and International Myeloma Society. He also leads educational initiatives like the Tutorial in Gene Therapy course.

Laboratory and Research Teams: His research group, operating at the interface of theory and experiment, collaborates closely with clinicians, computational biologists, and translational scientists within Mayo Clinic’s Comprehensive Cancer Center and William J. von Liebig Center for Transplantation. The team integrates systems biology, clinical data analytics, and experimental validation to drive innovation in hematologic malignancies.