David DiGregorio

David DiGregorio is a Principal Investigator in neuroscience at the Institut Pasteur in Paris, France, where he leads research on synaptic and cerebellar circuit dynamics. His work spans experimental and computational neuroscience, focusing on dendritic integration, synaptic diversity, and neural mechanisms of temporal and multisensory coding.

• Position: Principal Investigator
• Institution: Institut Pasteur, Paris
• Research Focus: Synaptic physiology, cerebellar circuits, dendritic computation, neural coding

His research interests center on understanding how synaptic and dendritic properties shape neural computations in the cerebellum. He investigates how the nanoscale organization of synaptic proteins, diversity in synaptic strength and plasticity, and dendritic integration contribute to information processing in neural circuits. His lab uses advanced techniques including patch-clamp electrophysiology, super-resolution microscopy (STED), 2-photon imaging in awake animals, and computational modeling. A key theme is how synaptic diversity enables temporal coding of multisensory inputs, a mechanism critical for motor coordination and cognitive behaviors.

His recent publications reveal a strong trend in exploring the structural and functional heterogeneity of synapses, the role of electrical synapses in synchrony, and the development of tools for imaging neurotransmitter dynamics. The articles span topics from molecular neuroscience to systems-level circuit modeling, reflecting an integrative approach to understanding brain function.

Notable scientific contributions include:

• Demonstrating that synaptic diversity enables temporal coding of multisensory inputs (Nature Neuroscience, 2015)
• Revealing sublinear dendritic integration in cerebellar interneurons (Neuron, 2012, 2016)
• Developing and applying glutamate sensors for in vivo imaging (Nature Methods, 2018)
• Modeling how synaptic diversity supports sub-second time representation (Nature Communications, 2022)

DiGregorio leads multiple ongoing projects funded by competitive grants, including an ERC Starting Grant (NEWRON). He mentors postdoctoral researchers and students, and his lab collaborates widely. He has developed methods for multi-site cerebellar recordings and two-photon neurotransmitter uncaging. His work is foundational for understanding how microcircuit properties enable precise neural representations of time and sensory context.

He is actively involved in the neuroscience community, organizing and presenting at seminars, and his lab is part of the broader neuroscience and neuroengineering initiatives at the Institut Pasteur. He has not been marked as retired or deceased, and there is no indication he is a former staff member or part-time appointee.