Danielle Swaney

Danielle Swaney serves as Associate Professor in the Department of Bioengineering and Therapeutic Sciences at the University of California San Francisco (UCSF), with dual appointments managing proteomics facilities at both the UCSF Weill Institute for Neurosciences and the Gladstone Institutes. Her research program operates within Nevan Krogan's laboratory ecosystem, providing access to comprehensive resources while maintaining focused small-lab mentorship. Dr. Swaney's work bridges advanced proteomic methodology development with diverse biological applications across infectious disease, neurodegeneration, and cancer research domains.

• Department of Bioengineering and Therapeutic Sciences
• UCSF Weill Institute for Neurosciences
• Gladstone Institutes (Visiting Scientist)

Dr. Swaney's research centers on proteomics approaches to investigate protein-protein interactions and post-translational modification signaling networks, with particular emphasis on infection biology and neurodegenerative processes. Her laboratory employs cutting-edge mass spectrometry techniques to map protein interaction networks and post-translational modifications across multiple disease contexts. Current research directions include viral pathogenesis mechanisms, bacterial infection strategies, Alzheimer's disease-related processes involving apoE4, and cancer signaling pathways.

Analysis of Dr. Swaney's recent publication record reveals consistent methodological innovation in proteomics technology coupled with diverse biological applications. Her work spans viral pathogenesis (particularly SARS-CoV-2 variants), bacterial infections (Chlamydia, Legionella, Mycobacterium tuberculosis), neurodegenerative mechanisms (Alzheimer's disease), and cancer biology (hepatocellular carcinoma, glioblastoma). A unifying theme across these diverse research areas is the application of advanced proteomic techniques to map protein interaction networks and post-translational modifications that drive disease processes.

Dr. Swaney actively contributes to major collaborative research initiatives including the Cancer Cell Map Initiative and various infectious disease research consortia. Her proteomics expertise supports multiple research teams across UCSF and the Gladstone Institutes, facilitating systems-level understanding of disease mechanisms through protein interaction mapping. She regularly collaborates with both basic science and clinical investigators to translate proteomic findings into potential therapeutic targets.

Dr. Swaney leads proteomics operations within the Krogan Lab ecosystem, managing state-of-the-art facilities at both the UCSF Weill Institute for Neurosciences and the Gladstone Institutes. Her team develops and applies innovative proteomic methodologies including affinity purification mass spectrometry on advanced platforms like the Orbitrap-Astral. Current research directions focus on improving protein interaction mapping resolution, developing novel approaches for post-translational modification analysis, and applying these techniques to understand disease mechanisms across multiple biological contexts.