Danielle Callaway

Danielle Callaway, M.D., Ph.D., is an Assistant Professor in the Department of Pediatrics at the University of Texas Southwestern Medical Center. Her research focuses on the effects of mechanical force on type 1 pulmonary epithelial (AT1) cells during lung development, integrating transgenic models, advanced imaging, and next-gen sequencing to improve neonatal care outcomes. Dr. Callaway's work originated from her postdoctoral studies in Dr. Edward Morrisey's lab at Children's Hospital of Philadelphia, where she explored AT1 cell functions beyond gas exchange.

Education:

• Bachelor's degree from University of Texas at Dallas
• M.D./Ph.D. from University of Texas Health San Antonio
• Pediatrics Residency at Baylor College of Medicine (with Pediatric Scientist Training Program)
• Neonatal-Perinatal Medicine Fellowship at Children's Hospital of Philadelphia

Research Interests: Combining developmental biology with clinical neonatology, Dr. Callaway investigates how mechanical forces influence AT1 cell behavior in pre/postnatal lung maturation. Her lab emphasizes redox biology pathways and cytochrome P450 regulation, particularly in hyperoxic environments. This work aims to address neonatal respiratory pathologies through mechanobiological insights.

Awards:

• NIH K08 Award (National Institutes of Health)

Lab & Future Work: The Callaway Lab employs cutting-edge techniques to study lung regeneration and extracellular matrix dynamics. Current projects explore transcriptional responses to mechanical stress in neonatal lungs and translational applications for premature infants. Future goals include developing therapies targeting AT1 cell dysfunction in respiratory distress syndromes.