Daniel MacPhee

Dr. Daniel MacPhee is a Professor and Head of the Department of Veterinary Biomedical Sciences at the Western College of Veterinary Medicine, University of Saskatchewan. His research focuses on placental development, uterine function during pregnancy, and stress protein signaling in reproductive tissues. He leads projects funded by NSERC (2023-2028) investigating chaperome proteins' roles in myometrial adaptation and placental health. Collaborations include work on PRRSV-2 infection mechanisms through the Swine Health Research Group and One Reproductive Health Group. Dr. MacPhee's lab trains students for careers in reproductive sciences, biotechnology, and veterinary medicine. He holds a B.Sc. (Hons.) from Prince Edward Island and a Ph.D. from Western Ontario.

Research Interests:
- Chaperome regulation of myometrial smooth muscle function during pregnancy
- Placental development and its implications for fetal health
- Extracellular vesicle-mediated communication in stress responses
- PRRSV-2 pathogenesis at the maternal-fetal interface
- Molecular mechanisms of inflammation in reproductive tissues

Key Projects:
- Investigating HSPB proteins' roles in inflammation and cytoskeletal regulation
- Examining stretch-induced extracellular vesicle production in myometrial cells
- Linking placental dysfunction to future adult diseases through fetal programming

Grants & Collaborations:
- NSERC-funded research on chaperome biology (2023-2028)
- Swine Health Research Group collaborations on viral infection models
- One Reproductive Health Group initiatives for interdisciplinary training

Lab Activities:
- Hosts a dynamic research team with openings for qualified trainees
- Emphasizes experimental design, data interpretation, and science communication
- Produces >15 peer-reviewed publications annually with student involvement