Dan Ehninger

Dr. Dan Ehninger serves as a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, where he leads research on aging-associated and neuropsychiatric disorders using multidisciplinary approaches. His laboratory employs mouse models combined with pharmacological, genetic, genomic, epigenomic, and molecular techniques to investigate disease pathogenesis and develop novel therapeutics.

Research interests span neurodegenerative diseases, aging mechanisms, and neuropsychiatric disorders, with specific focus on lifespan-regulatory pathways, epigenetic modifications, and translational applications. His work examines how age-related and environmentally induced epigenetic changes affect health outcomes across generations, utilizing physiological assessments, pathological analyses, and molecular biology techniques.

Scientific contributions include high-impact publications in journals such as Nature, Neuron, and PNAS. Key research themes include:

• mTOR pathway regulation in cognitive function
• Transgenerational epigenetic inheritance
• Pharmacological interventions for aging-related decline
• Mouse model development for neuropsychiatric disorders

The laboratory maintains strong translational focus, bridging preclinical findings to human populations through collaborative studies. Current projects investigate how epigenetic modifications interact with environmental factors to influence disease susceptibility across generations, with potential applications in preventive strategies for neurodegenerative conditions.