معرفی
Eric Miska is a Professor and Head of the Department of Biochemistry at the University of Cambridge. His research focuses on RNA biology, epigenetics, and genome stability, with a particular emphasis on small RNA mechanisms, transgenerational inheritance, and evolutionary adaptation. He leads a lab of ~15 researchers investigating topics such as RNA modifications (e.g., m6A), piRNA biology in germ cells, and the role of epigenetic plasticity in environmental adaptation.
- Current position: Head of Department of Biochemistry
- Research locations: Cambridge Biomedical Campus, Sanger Institute collaborations
His lab studies use C. elegans, fish models (Lake Malawi cichlids), and human/mouse systems to explore how RNA-based mechanisms regulate gene expression across generations. Recent work highlights roles for RNA modifications in splicing accuracy and transgenerational stress adaptation.
Key research themes include:
- RNA modifications: m6A's role in splicing and gene expression regulation
- Epigenetic inheritance: Mechanisms of transgenerational memory via small RNAs and chromatin
- Environmental adaptation: Genomic and epigenomic responses to temperature and stress
Publications over the past 3 years demonstrate contributions to RNA structural analysis (via rnaCrosslinkOO tools), histone chaperone functions, and evolutionary genomics of cichlid fish radiations. His lab's work frequently bridges molecular mechanisms with evolutionary biology, emphasizing the interplay between genetic and epigenetic systems.
