معرفی
Erica D Watson serves as Associate Professor in Reproductive Biology within the Department of Physiology, Development and Neuroscience at the University of Cambridge, leading a research program focused on transgenerational epigenetic inheritance mechanisms. Her work investigates how environmental factors—particularly abnormal folate metabolism—induce congenital malformations transmitted across generations using mouse models, with strong ties to the Cambridge Reproduction initiative.
Her research centers on epigenetic disruptions in germ cells and placental development, examining how folate deficiency alters DNA methylation patterns and causes neural tube, heart, and placental defects persisting in genetically normal descendants. Key specialties include epigenetics, developmental biology, and reproductive physiology, with emphasis on one-carbon metabolism's role in fetal programming and disease susceptibility across generations.
Analysis of her recent publications reveals consistent investigation into folate metabolism's impact on epigenetic stability, particularly in placental tissues and germ cells. Her work bridges molecular mechanisms (e.g., TET enzyme dynamics, retrotransposon regulation) with physiological outcomes like pregnancy loss and congenital disorders, predominantly utilizing genetically modified mouse models to dissect transgenerational disease pathways.
Scientific Awards: No specific awards were documented in the provided materials.
Advising and Grants: Student mentorship details and grant funding information are not specified in available sources.
Lab and Team: Dr. Watson directs a laboratory within the Department of Physiology, Development and Neuroscience, employing molecular biology techniques and mouse genetics to study transgenerational epigenetic inheritance. Her team collaborates through Cambridge Reproduction, focusing on environmental programming of developmental disorders with implications for human folic acid fortification policies.
