معرفی
Dr. Chris Wallace is a Wellcome Trust Senior Research Fellow at the University of Cambridge, affiliated with the Department of Medicine and the MRC Biostatistics Unit. Her research bridges statistical genomics and immune-mediated diseases, with a focus on developing computational tools for genetic analysis.
- Affiliation: Department of Medicine, University of Cambridge
- Affiliation: MRC Biostatistics Unit (Honorary Programme Leader)
- Affiliation: Cambridge Immunology Network
Her work addresses three major challenges: (1) joint analysis of immune-mediated diseases to identify shared/disease-specific risk components, (2) mapping disease-associated variants to cell-specific mechanisms, and (3) modeling immune dysregulation for therapeutic insights. Statistical innovations include Bayesian model averaging, matrix factorization, and empirical Bayes false discovery rates.
Key research trends from her publications include multi-trait genetic analysis, cell-type-specific eQTL mapping, and machine learning applications in immunology. Recent projects explore polymorphic tandem repeats, deep learning for polygenic scores, and colocalization methods with functional priors.
Scientific Awards
- Wellcome Trust Senior Research Fellow
- British Heart Foundation Fellowship
Dr. Wallace actively contributes to the MRC-funded CLUSTER programme for stratified medicine, collaborating with institutions like GOSH, QMUL, and universities in Manchester and Liverpool. Her methodologies have advanced genetic risk prediction, seroprevalence estimation, and data sharing practices in genomics research.
