معرفی
Professor Chris Halsey serves as Head of School and Professor of Paediatric Haemato-Oncology within the School of Cancer Sciences at the University of Glasgow. Based at the Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre in Garscube Estate, Professor Halsey leads the Childhood Leukaemia Research Group (Halsey Lab) focused on understanding childhood leukemia biology and developing improved therapeutic approaches.
Professor Halsey's research primarily centers on childhood acute lymphoblastic leukemia (ALL), with particular emphasis on central nervous system (CNS) involvement. His work investigates how leukemia cells adapt metabolically to survive in the CNS microenvironment, with significant findings regarding cholesterol biosynthesis pathways in CNS leukemia. His research also explores molecular mechanisms of leukemia cell migration to the CNS, treatment resistance in the bone marrow niche, and development of targeted therapies including immunotherapeutic approaches. His lab employs advanced techniques including hiPSC-derived models, lipidomics, and single-cell tracking to understand leukemia biology.
Analysis of Professor Halsey's recent publications reveals consistent focus on CNS involvement in childhood leukemia, with particular attention to metabolic adaptations that allow leukemia cells to survive in the CNS compartment. His research spans from basic molecular mechanisms to translational applications, with several recent studies identifying potential therapeutic targets for CNS-directed therapy. His collaborative work extends across multiple international research groups, with significant contributions to understanding T-cell ALL, MLL-rearranged leukemia, and treatment toxicity.
Professor Halsey has secured substantial research funding from numerous prestigious organizations including Children's Cancer and Leukaemia Group, Medical Research Council, Cancer Research UK, Wellcome Trust, and others. His current grants (running through 2025-2026) focus on topics such as CRYSTAL-Immune Pump-Priming, metabolic reprogramming for CNS-directed therapy, identification of biomarkers for personalized treatment, and understanding drivers of CNS involvement in T-ALL. His research program demonstrates strong translational focus with direct implications for improving clinical outcomes in childhood leukemia.
Based at the Wolfson Wohl Cancer Research Centre, Professor Halsey leads the Childhood Leukaemia Research Group which maintains active collaborations across multiple institutions. His team utilizes state-of-the-art approaches including lipidomic analysis, hiPSC-derived models, and advanced sequencing techniques to investigate leukemia biology. The lab's work bridges basic science with clinical applications, with several ongoing studies designed to translate laboratory findings into improved patient care.
