Charilaos Filippakis

Charilaos (Harry) Filippakis is an Assistant Professor in the Department of Biomedical Sciences at the University of New England’s College of Osteopathic Medicine (COM), located on the Biddeford Campus. His research focuses on macropinocytosis, lysosomal metabolism, and autophagy in mTORC1-hyperactive cells, employing metabolomic, proteomic, and transcriptomic methodologies along with in vivo models. He holds a Ph.D. in Molecular Basis of Human Disease from the University of Crete (Greece) and completed postdoctoral training at Tufts Medical Center and Brigham & Women’s Hospital/Harvard Medical School, studying oncogenic viruses, chromosomal instability, and nutrient recycling in TSC/LAM pathogenesis.

Education:

• Bachelor’s Degree (Hons) in Genetics, University of Aberdeen, Scotland
• Ph.D., Molecular Basis of Human Disease, University of Crete Medical School, Greece

Research Interests: His lab explores mechanisms of aberrant mTORC1 activation, metabolic reprogramming in TSC/LAM, and cancer metabolism. Key areas include understanding how macropinocytosis and lysosomal pathways contribute to disease progression in these conditions.

Funding & Grants: Supported by The LAM Foundation and the Department of Defense Kidney Cancer Research Program. His work integrates multi-omics approaches to dissect cellular metabolic pathways in disease states.

Labs/Teams: Directs the Filippakis Lab (filippakislab.org), focused on translational research in metabolic and genetic disorders.