Constantinos Demetriades

Constantinos Demetriades, PhD, is a Research Group Leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany, holding an academic rank equivalent to Associate Professor. He is also an Associated Principal Investigator at the CECAD Research Center, University of Cologne. His research focuses on the molecular mechanisms of cell growth, metabolism, and aging, primarily through the mTORC1 signaling pathway.

• Doctorate (Ph.D), 2003–2009: Institute of Immunology, Biomedical Sciences Research Center (BSRC) 'Alexander Fleming' & Department of Genetics, Development and Molecular Biology, Aristotle University of Thessaloniki
• Degree in Biology, 1999–2003: School of Biology, Aristotle University of Thessaloniki, Greece

Dr. Demetriades' research investigates how cells sense nutrients and stress to regulate growth via the TSC/mTOR signaling hub. His work combines high-throughput omics with advanced molecular and cell biology techniques using human and mouse models. Key interests include nutrient sensing, lysosomal signaling, unconventional protein secretion, and metabolic regulation in aging and disease. His recent publications reveal novel mechanisms such as the role of Malonyl-CoA as an endogenous mTORC1 inhibitor and the spatial regulation of mTORC1 by amino acids.

His research output shows a consistent focus on mTORC1 regulation, lysosomal dynamics, and stress response, with a trend toward understanding metabolic inputs and unconventional cellular processes. Publications in top journals like Nature Cell Biology and Molecular Cell highlight his contributions to cell signaling and aging research.

• Walther Flemming Award, German Society for Cell Biology (DGZ), 2019
• ERC Starting Grant, European Research Council, 2018–2023
• ERC Proof of Concept Grant, 2024–2025
• Heineman Project Grant, Minna-James-Heineman & Minerva Foundation, 2019–2022
• Research Unit FOR2722 Grant, German Research Foundation (DFG), 2022–2025
• ANR-DFG Collaborative Research Grant, 2023

Dr. Demetriades has secured substantial competitive funding, including ERC and DFG grants, supporting his independent research program. He leads a research team focused on fundamental mechanisms in aging and disease. While specific advisees are not listed, his group conducts high-impact research in cell growth and metabolism. He has not been mentioned as advising specific students in the provided text.

He leads the Max Planck Research Group Demetriades, which investigates cell growth control in health and age-related disease. The lab employs functional genomics, proteomics, and advanced imaging to study mTOR signaling, lysosomal function, and stress responses. Team photos and lab events indicate an active research environment.