معرفی
Catharine Duman is a Psychiatry Clinical Instructor at Yale University’s Yale School of Medicine. She holds a PhD from Wesleyan University (1995). Her research focuses on neurobiological mechanisms underlying depression, with emphasis on synaptic plasticity, antidepressant drug mechanisms, and stress effects. Key areas include studying ketamine’s rapid-acting antidepressant effects, GABAergic signaling, and mTORC1 pathways.
- Affiliations: Connecticut Mental Health Center, Yale School of Medicine
- Education: PhD in Neuroscience (Wesleyan University, 1995)
Research interests span molecular neurobiology, pharmacology, and translational psychiatry. Her work explores synaptic remodeling in depression, stress-induced neural changes, and novel antidepressant targets like Sestrin modulators. Collaborations include studies with Rosemarie Terwilliger, Xiao-Yuan Li, and Marina Picciotto.
Publications highlight contributions to understanding ketamine’s cellular triggers, 5-HT1A receptor signaling, and REDD1’s role in synaptic loss. She has investigated antidepressant effects of GLYX-13 and exercise-induced behavioral changes.
