معرفی
Todd D. Gould is a Professor in the Department of Psychiatry at the University of Maryland School of Medicine, holding secondary appointments in Neurobiology and Pharmacology. His research laboratory investigates mood disorder pathophysiology and mechanisms of psychiatric medications using multidisciplinary approaches.
Education:
- MD from the University of Virginia
- Postdoctoral fellowship at the National Institute of Mental Health Laboratory of Molecular Pathophysiology and Experimental Therapeutics
Research Focus: Dr. Gould's work centers on understanding how mood stabilizers and antidepressants like lithium and ketamine exert their therapeutic effects, with particular emphasis on ketamine metabolites such as (2R,6R)-hydroxynorketamine. His laboratory employs genetic, pharmacological, biochemical, electroencephalographic, and behavioral methodologies to develop improved animal models for psychiatry and investigate functional consequences of mood disorder susceptibility genes. Key research areas include Depression, Bipolar Disorder, Antidepressant Pharmacology, and synaptic plasticity mechanisms.
Analysis of his recent publications (2023-2025) reveals a dominant focus on ketamine's metabolites as rapid-acting antidepressants, exploring their unique synaptic effects independent of NMDA receptor blockade. His work increasingly examines estradiol signaling in stress susceptibility and depression pathophysiology, particularly in male models, while advancing hydroxynorketamine's clinical translation through pharmacokinetic and safety studies.
Laboratory: Dr. Gould directs the Gould Lab (www.gouldlab.org), which maintains active collaborations with clinical research groups to bridge translational neuroscience and psychiatric treatment development.
