Carolyn Mattingly

Carolyn Mattingly is a Distinguished Professor at North Carolina State University (NC State) and a University Faculty Scholar. She serves as Director of the Center for Environmental and Health Effects of PFAS, an NIEHS-funded Superfund Research Program, and leads the Comparative Toxicogenomics Database (CTD). Her research focuses on environmental exposures' impact on human health, particularly PFAS toxicity and molecular mechanisms linking chemicals to diseases like cancer and neurodevelopmental disorders. Mattingly earned a BA in Art History from Oberlin College and a PhD in Molecular Toxicology from Tulane University, followed by postdoctoral training in Pharmacology at Weill Cornell Medicine.

Her work integrates computational biology, toxicology, and environmental science to develop tools like CTD, which maps chemical-gene-disease relationships. She has pioneered exposure science ontology (ExO) and advanced AI-driven text mining for data curation. Recent projects include studying cadmium's effects on zebrafish development and developing tetramer tools for molecular inference.

Mattingly leads interdisciplinary teams at NC State’s Superfund Center and the Center for Human Health and the Environment (CHHE). She has received the 2017 University Faculty Scholar award and contributed to over 100 peer-reviewed studies. Her grants and collaborations span environmental health, exposomics, and public health policy, emphasizing translation of scientific findings into actionable community strategies.