معرفی
Caroline E. Goutte is a Professor of Biology at Amherst College, specializing in molecular and developmental biology. Her research focuses on Notch signaling pathways in Caenorhabditis elegans, particularly the role of gamma-secretase complex components like APH-1 and APH-2/Nicastrin. She has led NSF-funded projects on cellular communication mechanisms and gamma-secretase function.
Education:
- Ph.D., University of California, San Francisco, Biochemistry (1992)
- B.A., Cornell University, Biology (1985)
- Postdoctoral Fellow, Fred Hutchinson Cancer Research Center (1992-1996)
Her teaching spans introductory biology courses (e.g., Molecules, Genes, and Cells) to advanced seminars in Developmental Genetics. Research interests include genetic analysis of cell interactions, with recent work redefining the role of APH-2 in gamma-secretase activity. Over 20 student researchers have co-authored her publications.
Awards:
- NSF MRI Award (2021, Co-PI) for microscopy infrastructure
- NSF RUI Award (2002-2006, PI) for Notch signaling studies
- Trustee Faculty Fellowship (1999–2000)
Her lab employs CRISPR/Cas9 engineering and fluorescence microscopy to study protein localization in C. elegans embryos. Current projects explore gamma-secretase’s modulatory roles in developmental signaling.
