معرفی
Carl P. Blobel is a Professor of Medicine, Physiology, Biophysics, and Systems Biology at Weill Cornell Medical College, and Chairman of the Arthritis and Tissue Degeneration Program at the Hospital for Special Surgery in New York City. He holds the V.F. and W.R. Salomon Endowed Chair in Musculoskeletal Research. His research focuses on ADAM metalloproteinases, particularly their roles in development, inflammation, and disease, including cancer and autoimmune disorders like rheumatoid arthritis. Blobel's work combines biochemical, cell biological, and mouse model approaches to elucidate ADAM17's regulation by iRhom proteins and its impact on EGFR and TNF-α signaling.
Education and Career: MD from Justus-Liebig University (1984), PhD in Biochemistry (UCSF, 1991). Established his lab at Sloan-Kettering Institute (1992), moved to Weill Cornell/Hospital for Special Surgery in 2004. Current roles include leadership in translational research and training.
Research Highlights: Pioneered studies on ADAM17's role in EGFR signaling pathways critical for skin and intestinal barriers, and its dysregulation in disease. Discovered iRhom1/2 as key upstream regulators of ADAM17 activity, impacting both cancer and autoimmune therapies. Major contributions to understanding TNF-α shedding in inflammation and hemophilic arthropathy.
Awards: Association of American Physicians (2015), Bayer Hemophilia Award (2012), Gordon Conference Chair (2009), NIH Shannon Award (1996). His work has identified novel therapeutic targets for diseases like rheumatoid arthritis and EGFR-driven cancers.
Publications: Over 100 peer-reviewed articles, with recent focus on ADAM10's role in vascular development and Notch signaling, iRhom2's dual impact on TNF-α and EGFR pathways, and mechanisms of blood-induced joint damage in hemophilia.
