معرفی
Dr. Lionel B. Ivashkiv is a leading academic and physician-scientist, serving as Professor of Medicine and Immunology at Weill Cornell Medicine and holding dual leadership roles as Chief Scientific Officer at Hospital for Special Surgery (HSS) and Director of the David Z. Rosensweig Genomics Research Center at HSS. His research bridges basic science and translational medicine, focusing on cytokine signaling, epigenetic regulation of inflammation, and therapeutic targets for musculoskeletal disorders.
- Education: MD from Harvard Medical School, Residency at NYU/Bellevue Hospital, Fellowship at Brigham and Women's Hospital
Dr. Ivashkiv's laboratory investigates how cytokines like IFN-γ, IFN-α, IL-10, and TNF regulate innate immune and stromal cell functions (macrophages, osteoclasts, synovial fibroblasts). Key themes include:
- Jak-STAT signaling crosstalk
- Epigenomic mechanisms in inflammatory gene expression
- Macrophage reprogramming (priming/tolerance)
- Autoimmune disease pathogenesis (rheumatoid arthritis, lupus)
- Translational genomics (RNA-seq, ChIP-seq, ATAC-seq)
- Precision medicine approaches for individualized therapies
His team employs innovative methods combining bacterial artificial chromosomes (BACs) with CRISPR-Cas9 to study human autoimmunity-associated genes like A20/TNFAIP3. Recent publications highlight discoveries in:
- Cytokine-driven inflammation in arthritis and implant failure
- Lipid metabolism regulation in T cells
- Novel strategies for preventing peri-implant fibrosis
- Interferon-γ and PGE2-cAMP axis interactions
- Epigenetic modulation of immune cell phenotypes
- Mechanosensing in plasmacytoid dendritic cells
Scientific honors include election to the Association of American Physicians and American Society for Clinical Investigation, alongside multiple awards from the Arthritis Foundation and NIH. He leads multidisciplinary teams studying clinical challenges such as:
- Rheumatoid arthritis flares and therapy resistance
- Orthopedic implant aseptic loosening
- Total knee replacement complications
- Spine degeneration and pain
