معرفی
Carl Blobel is a Professor of Medicine and of Biochemistry, Cellular and Molecular Biology at Weill Cornell Medicine, and a Senior Scientist and Program Director at the Hospital for Special Surgery (HSS) in New York. He holds the Virginia F. and William R. Salomon Chair in Musculoskeletal Research and leads the Arthritis and Tissue Degeneration Program at HSS. His work bridges clinical and basic science, focusing on the molecular mechanisms of autoimmune diseases and tissue degeneration.
Education:
- MD, Justus-Liebig University, Giessen, Germany
- PhD in Biochemistry and Biophysics, University of California, San Francisco (UCSF)
Dr. Blobel's research centers on the iRhom/ADAM17 signaling axis, a critical regulator of TNFα, IL-6R, and EGFR signaling pathways. These pathways are central to autoimmune diseases such as rheumatoid arthritis and lupus nephritis, as well as cancer and neuroinflammation. His lab employs a multidisciplinary approach combining biochemistry, cell biology, mouse models, and patient sample analysis to understand how iRhoms and ADAM17 regulate protein ectodomain shedding and influence disease progression.
His recent publications highlight the role of iRhom2 in lupus nephritis, hemophilic arthropathy, and inflammatory arthritis, demonstrating its potential as a therapeutic target. The work consistently emphasizes translational relevance, leading to the co-founding of SciRhom, a biotech startup developing function-blocking antibodies against iRhom2.
Scientific Awards and Honors:
- Elected Member, Association of American Physicians (2015)
- Distinguished Affiliated Professorship, Technical University of Munich (2017)
- Hans Fischer Senior Fellowship Award, Institute of Advanced Studies, TUM
- Bayer Hemophilia Special Project Award
Dr. Blobel has been continuously funded by the NIH, including a MIRA award (R35 GM134907), and holds advisory and royalty relationships with biotech companies such as SciRhom GmbH, Kerafast, and Millipore. He leads an active research laboratory at HSS and has made seminal contributions to the understanding of regulated membrane proteolysis. His h-index of 70 and over 15,000 citations reflect his significant impact in the field.
Laboratory and Research Programs:
Dr. Blobel leads the Laboratory for Disc Repair Strategies at HSS and directs the Arthritis and Tissue Degeneration Program. His lab is part of the broader research ecosystem at HSS and Weill Cornell Medicine, contributing to both basic science discovery and clinical translation.
