معرفی
Brian Eckenroth is a Researcher in the Department of Microbiology and Molecular Genetics at the Larner College of Medicine, University of Vermont. His work focuses on the structural biology of DNA replication and repair enzymes, particularly those involved in maintaining genomic stability and preventing cancer development.
- Recipient of the National Cancer Institute R50 award (R50 CA233185)
- Specializes in X-ray crystallography and biochemical analysis of DNA repair proteins
- Active in technical training and facility management for structural biology equipment
Research Interests
Brian's research examines the molecular mechanisms of enzymes that repair DNA damage, including NEIL1-3 glycosylases and DNA polymerase beta. His work combines structural determination with functional analysis to understand error-prone repair pathways in cancer contexts.Publications
Recent studies highlight his expertise in structural characterization of novel DNA repair enzymes like Thermococcus kodakarensis AP lyase and functional analysis of bromodomains in epigenetic regulation. Collaborative work spans from microbial sporulation (Clostridioides difficile) to human DNA repair systems.Awards
- NIH/NCI R50 Research Specialist Grant
Training and Infrastructure
Brian provides technical training in X-ray diffraction equipment maintenance and serves as a day-to-day resource for structural biology researchers. His facility management role supports investigations across diverse molecular targets.۰مقاله منتشرشده
