Millie M. Georgiadis

Millie M. Georgiadis, Ph.D. is a Professor of Biochemistry and Molecular Biology at Indiana University's School of Medicine. Her research focuses on protein-nucleic acid interactions and their role in fundamental biological processes with translational applications.

Education:

• B.S., Indiana University 1984
• Ph.D., University of California, Los Angeles 1990

Dr. Georgiadis's research spans multiple areas of molecular biology, with particular focus on protein-nucleic acid interactions in retroviral systems and DNA repair mechanisms. Her laboratory investigates the role of these interactions in replication, nuclear export, and gene expression regulation. Early work centered on retroviral life cycles, particularly reverse transcriptase and nuclear export mechanisms. More recently, her research has expanded into DNA repair mechanisms, especially Ref-1/APE1 biology, with implications for cancer therapeutics and eye disease.

Analysis of her 15 most recent publications (2014-2025) reveals a strong shift toward translational research in Ref-1/APE1 biology. Her work has evolved from fundamental structural studies to therapeutic applications targeting DNA repair pathways. The interdisciplinary nature of her research bridges structural biology, biochemistry, and pharmacology, with increasing emphasis on drug discovery and clinical applications for cancer and neovascular eye diseases.

Key Research Areas:

• Protein-nucleic acid interactions in retroviral replication
• Structural biology of DNA repair enzymes
• Ref-1/APE1 in redox signaling and DNA repair
• Development of inhibitors targeting DNA repair pathways
• Translational applications in oncology and ophthalmology

Dr. Georgiadis has been involved in numerous collaborative research projects, particularly in developing novel therapeutics targeting DNA repair mechanisms. Her laboratory maintains expertise in X-ray crystallography combined with biochemical approaches to study enzyme mechanisms. Recent work shows strong connections with clinical researchers in oncology and ophthalmology, demonstrating the translational impact of her basic science discoveries.

Her laboratory, part of the Center for Structural Biology at Indiana University, continues to be highly productive with publications through 2025, indicating an active and evolving research program that bridges fundamental science and clinical applications.