معرفی
Brent Johnston is a Professor and Department Head in the Department of Microbiology & Immunology at Dalhousie University, Faculty of Medicine. His research focuses on immune cell development, homing, and activation, particularly investigating NKT cells' role in autoimmunity and anti-tumour responses. He holds a BSc and PhD from the University of Calgary, with postdoctoral training at Stanford University.
Research interests include cancer immunology, cytokine/chemokine regulation, and inflammatory mechanisms. Recent work emphasizes combining natural killer T (NKT) cell immunotherapy with oncolytic viruses and immune checkpoint inhibitors to combat pancreatic and breast cancers. His studies also explore Pseudomonas aeruginosa lung infections and γδ T cell functions.
Key publications highlight synergistic therapeutic approaches targeting metastatic cancers and inflammatory diseases. Awards include a Canada Research Chair (2004–2014) and the David T. Janigan Teaching Award (2011). His work bridges basic immunology with translational cancer therapies, emphasizing NKT cell biology and chemokine receptor pathways.
- Education:
- BSc, University of Calgary
- PhD, University of Calgary
- Postdoctoral Training, Stanford University
- Awards:
- Canada Research Chair in Inflammation and Immunity (2004–2014)
- David T. Janigan Teaching Award (2011)
Advances in NKT cell immunotherapy and oncolytic virotherapy are central to his lab's research, with ongoing efforts to optimize combination therapies for solid tumors and metastatic disease.
